1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene → 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochlorid

HRID 6188

Reaction equation

HRID 6188 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]([C:35](=[O:38])[CH2:36][CH3:37])[CH2:24][CH2:25][CH2:26][CH2:27][S:28][C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[C:13](=[O:16])[CH2:14][CH3:15])=[CH:3][CH:2]=1.[ClH:39].CO>CO>[ClH:39].[ClH:39].[N:1]1[CH:6]=[CH:5][C:4]([S:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[N:23]([C:35](=[O:38])[CH2:36][CH3:37])[CH2:24][CH2:25][CH2:26][CH2:27][S:28][C:29]2[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=2)[C:13](=[O:16])[CH2:14][CH3:15])=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 190791281,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzeneHCID 21893726Hydrochloride methanol

Product 1

HCID 190792291,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene dihydrochloridYield 74.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 840 mg (1.53 mmol) of 1,2-bis[N-[4-(4-pyridylthio)butyl]-N-propionylamino]benzene in 20 ml of methanol, 80 ml of 10% hydrochloric acid/methanol was added, and the mixture was stirred for 30 minutes. The solvent was distilled off and the residue was recrystallized from ethanol/ether to give 707 mg of the desired product (74.1% yield, pale yellow crystals).

Workup

  1. distillationThe solvent was distilled off
  2. customthe residue was recrystallized from ethanol/ether

Sources & evidence

ORD record
ord-84de096b7dbe4838b438dd20613401fa
Source dataset
uspto-grants-1993_09
Patent number
US05246948

Linked notes

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