Benzonitrile, 4-chloro-3-nitro- → 6-Cyano-2-[1-(6-methoxy-pyridin-2-yl)-1-methyl-ethyl]-1H-indole-3-carboxylic acid tert-butyl ester

HRID 61896

Reaction equation

HRID 61896 reaction equation
[C:1]([O:5][C:6](=[O:21])[CH2:7][C:8](=O)[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[N:13]=1)([CH3:11])[CH3:10])([CH3:4])([CH3:3])[CH3:2].Cl[C:23]1[CH:30]=[CH:29][C:26]([C:27]#[N:28])=[CH:25][C:24]=1[N+:31]([O-])=O>>[C:1]([O:5][C:6]([C:7]1[C:23]2[C:24](=[CH:25][C:26]([C:27]#[N:28])=[CH:29][CH:30]=2)[NH:31][C:8]=1[C:9]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([O:18][CH3:19])[N:13]=1)([CH3:11])[CH3:10])=[O:21])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 13655Benzonitrile, 4-chloro-3-nitro-HCID 668345394-(6-Methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester

Product 1

HCID 668346136-Cyano-2-[1-(6-methoxy-pyridin-2-yl)-1-methyl-ethyl]-1H-indole-3-carboxylic acid tert-butyl ester

Procedure

According to the method that is used for the preparation of Compound PR5-1, the title compound was synthesized from 4-(6-methoxy-pyridin-2-yl)-4-methyl-3-oxo-pentanoic acid tert-butyl ester and 4-chloro-3-nitrobenzonitrile

Workup

  1. customis used for the preparation of Compound PR5-1

Sources & evidence

ORD record
ord-2d141fc0d07144d0bcb2ce9c15496642
Source dataset
uspto-grants-2016_09
Patent number
US09440922B2

Linked notes

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