Thiourea → 4-(2-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide

HRID 619077

Reaction equation

HRID 619077 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:6]=1[F:15])=O.[NH2:16][C:17]([NH2:19])=[S:18]>CO>[BrH:1].[F:15][C:6]1[CH:7]=[CH:8][C:9]([C:11]([F:14])([F:13])[F:12])=[CH:10][C:5]=1[C:3]1[N:16]=[C:17]([NH2:19])[S:18][CH:2]=1

Participants

4

Reactant 2

HCID 2723790ThioureaHCID 27787842-Fluoro-5-(trifluoromethyl)phenacyl bromide

Product 1

HCID 218455954-(2-Fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 5.8 g of 2-bromo-1-(2-fluoro-5-trifluoromethyl-phenyl)-ethanone in 44 ml of methanol was treated at room temperature with 2.2 g of thiourea and boiled for 1 hour. 2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals upon cooling to 0° C. and after the addition of 15 ml of diethyl ether.

Workup

  1. custom2.8 g of 4-(2-fluoro-5-trifluoromethyl-phenyl)-thiazol-2-ylamine hydrobromide separated as colorless crystals
  2. additionafter the addition of 15 ml of diethyl ether

Sources & evidence

ORD record
ord-f4535cf8a7314c42ba0ce4655d0e8876
Source dataset
uspto-grants-1999_09
Patent number
US05958910

Linked notes

Loading…