Aluminium lithium hydride → HCID 21995277, compound
Reaction equation
OCC1C=CC(C2C=CN=C(NC3C=C(OC)C(OC)=C(OC)C=3)N=2)=CC=1.C([O:35][C:36]([CH2:38][C:39]1[CH:44]=[CH:43][C:42]([NH:45][C:46]2[CH:51]=[CH:50][N:49]=[C:48]([NH:52][C:53]3[CH:58]=[C:57]([O:59][CH3:60])[C:56]([O:61][CH3:62])=[C:55]([O:63][CH3:64])[CH:54]=3)[N:47]=2)=[CH:41][CH:40]=1)=O)C1C=CC=CC=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>>[OH:35][CH2:36][CH2:38][C:39]1[CH:44]=[CH:43][C:42]([NH:45][C:46]2[CH:51]=[CH:50][N:49]=[C:48]([NH:52][C:53]3[CH:54]=[C:55]([O:63][CH3:64])[C:56]([O:61][CH3:62])=[C:57]([O:59][CH3:60])[CH:58]=3)[N:47]=2)=[CH:41][CH:40]=1Participants
4
Procedure
In a manner analogous to the preparation of the compound of Example 62 (267 mg, 0.5 mmol) from the compound of Example 106 and LiAlH4 (40 mg, 1.1 mmol) to give the title compound (108 mg) as a light pink solid m.p. 172°. MS m/z 397 (M+H)+.