Methyl iodide → 1,1-Dimethyl-3-hydroxypiperidinium Chloride

HRID 619979

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][CH2:5][N:4]([CH3:8])[CH2:3]1.IC.[CH2:11](Cl)[Cl:12]>>[Cl-:12].[CH3:8][N+:4]1([CH3:11])[CH2:5][CH2:6][CH2:7][CH:2]([OH:1])[CH2:3]1

Participants

Reactant 3

HCID 6328Methyl iodide

HCID 6344Dichloromethane

HCID 980163-Piperidinol, 1-methyl-

Product 1

HCID 212474851,1-Dimethyl-3-hydroxypiperidinium Chloride

Procedure

This compound was prepared by the procedure described for 2-[4-(N,N,N-trimethylammonium)phenyl]ethanol chloride. Typical reagent levels were as follows: 3-hydroxy-1-methylpiperidine (21.7 g, 0.188 mol), iodomethane (40.0 g, 0.280 mol) and methylene chloride (50 ml).

Workup

customThis compound was prepared by the procedure

Sources & evidence

ORD record: ord-0f06b4d483da430bbc56756d0f569330
Source dataset: uspto-grants-1989_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04818426

Linked notes

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