HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178488135, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4-Chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride | HCID 21245798 | — |
| Reactant | HCID 178488032 | HCID 178488032 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178488135 | HCID 178488135 | — |
Reaction Steps
A mixture of 4-chloromethyl-5-methyl-6-piperidino pyrimidine hydrochloride (4.63 g) and 2-mercapto-5-methoxybenzimidazole (3.18 g) in ethanol (180 ml) were heated at 50° for 5 hours. The solution was stripped to a residual glass, to which water was added, the pH raised to 13 (NaOH), and extracted with chloroform. Extracts were dried (K2CO3) and stripped to a residual glass which crystallised from ethyl acetate to give 5-methoxy-2-(5-methyl-6-piperidino-4-pyrimidinylmethylthio)-(1H)-benzimidazole, 5.67 g, m.p. 94°-96°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820708 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-f0b3cf19a26540c096a9c51b2ed7d5be |
| Source note | uspto-grants-1989_04 |