HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Naphthaleneacetonitrile → 8-Piperidino-2-(1-naphthyl)-octanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Naphthaleneacetonitrile | HCID 8596 | — |
| Reactant | Sodium amide | HCID 24533 | — |
| Reactant | 1-(6-Chlorohexyl)piperidine | HCID 13806003 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 8-Piperidino-2-(1-naphthyl)-octanenitrile | HCID 21245867 | — |
Reaction Steps
3.9 g of sodium amide are added in small quantities to 16.7 g of 1-naphthyl-acetonitrile in solution in 200 ml of anhydrous ether. After 2 hours of heating to reflux, 20.5 g of 6-piperidino-1-chloro-hexane are added and heating is continued to reflux for another 5 hours. Then, using the conventional methods, 30 g of product are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04820717 |
| Source dataset | uspto-grants-1989_04 |
| ORD ID | ord-d01eca2758cf4f3cb0af6e293f6d41bb |
| Source note | uspto-grants-1989_04 |