(1-Chloroethyl)benzene → 1-(3-Vinylphenyl)-1-phenylethane

HRID 620967

Reaction equation

HRID 620967 reaction equation
Cl[CH:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)[CH3:3].[CH:10]([C:12]1[CH:13]=[C:14]([Mg]Br)[CH:15]=[CH:16][CH:17]=1)=[CH2:11]>>[CH:2]([C:4]1[CH:9]=[C:8]([CH:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[CH:7]=[CH:6][CH:5]=1)=[CH2:3]

Participants

3

Reactant 2

HCID 12648(1-Chloroethyl)benzene2×HCID 178436337HCID 178436337, compound2×

Product 1

HCID 147502581-(3-Vinylphenyl)-1-phenylethane

Procedure

(1-Chloroethyl)benzene (formula VI) is subjected to coupling reaction with a Grignard reagent of 3-vinylphenylmagnesium bromide (formula VII) in the presence of a catalyst of nickel chloride (II)-diphosphine complex, to obtain 1-(3-vinylphenyl)-1-phenylethane. The reaction is carried out in a nitrogen atmosphere under atmospheric pressure at a temperature of 0° to 80° C. The ratio of (VI)/(VII) may be in the range of about 1.0 to 1.5. ##STR9##

Sources & evidence

ORD record
ord-c751cc797d1948abb698a6f491abf4ef
Source dataset
uspto-grants-1989_04
Patent number
US04822934

Linked notes

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