Benzenepropanoyl chloride → HCID 1787923, compound
Reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[NH:2][NH2:3].[C:7]1([CH2:13][CH2:14][C:15](Cl)=[O:16])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(#N)C>[C:7]1([CH2:13][CH2:14][C:15]([NH:3][NH:2][C:1]([O:5][CH3:6])=[O:4])=[O:16])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
To a solution of 18 g. (0.2 moles) of methyl carbazate and 100 ml. of acetonitrile 33.7 g. (0.2 moles) of β-phenyl-propionyl chloride are added dropwise. The reaction mixture is heated to boiling for 15 hours, clarified and cooled. The crystals are filtered off. Thus 36.85 g. of the desired compound are obtained, yield 80.7%, m.p.: 118° C.
Workup
- temperatureThe reaction mixture is heated
- temperaturecooled
- filtrationThe crystals are filtered off
Sources & evidence
- ORD record
- ord-e825e9d503154cf98f041cb3298fda70
- Source dataset
- uspto-grants-1989_04
- Patent number
- US04824670
Reaction notes
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