1-Allyloxy-4-methoxybenzene → 3-(1H-Imidazol-1-ylmethyl)-5-[(4-methoxyphenoxy)methyl]-2-methyl-3-(2-thienyl)isoxazolidine

HRID 622185Notes

Reaction equation

HRID 622185 reaction equation
[N:1]1([CH2:6][C:7]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)=[N+:8]([O-:10])[CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1.[CH3:16][O:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH:26]=[CH2:27])=[CH:20][CH:19]=1>>[N:1]1([CH2:6][C:7]2([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH2:27][CH:26]([CH2:25][O:24][C:21]3[CH:22]=[CH:23][C:18]([O:17][CH3:16])=[CH:19][CH:20]=3)[O:10][N:8]2[CH3:9])[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

3

Reactant 2

HCID 2886701-Allyloxy-4-methoxybenzeneHCID 855509281-(2-thienyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide

Product 1

HCID 212939253-(1H-Imidazol-1-ylmethyl)-5-[(4-methoxyphenoxy)methyl]-2-methyl-3-(2-thienyl)isoxazolidine

Procedure

Compound 6 (R=CH2OC6H4OCH3 -4) can be prepared by a method similar to that described in Example 1 by reacting 2-(1H-imidazol-1-yl)-N-methyl-1-(2-thienyl)ethanimine N-oxide (4) with allyl 4-methoxyphenyl ether.

Sources & evidence

ORD record
ord-2670f30dbcc34e0283a22fd3714c16b6
Source dataset
uspto-grants-1988_09
Patent number
US04769470

Reaction notes

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