Piperazin-2-one → 2-(3-Oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride
Reaction equation
[O:1]=[C:2]1[CH2:7][NH:6][CH2:5][CH2:4][NH:3]1.Cl.[Cl:9][CH2:10][C:11](=[NH:14])OC>CO>[ClH:9].[O:1]=[C:2]1[NH:3][CH2:4][CH2:5][N:6]([C:11](=[NH:14])[CH2:10][Cl:9])[CH2:7]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
8.64 g of 2-oxopiperazine were added to a solution of 12.4 g of methyl 2-chloroacetimidate hydrochloride in 44.8 ml of anhydrous methanol, and the mixture was stirred at room temperature for 2 hours. After completion of the reaction, a small amount of insoluble material was filtered off and the solvent was distilled off from the filtrate. Ether was added to the residue, and the precipitated crystals were collected by filtration and washed with ether, giving 18.0 g of 2-(3-oxopiperazin-1-yl)-2-iminoethylchloride hydrochloride.
Workup
- customAfter completion of the reaction
- filtrationa small amount of insoluble material was filtered off
- distillationthe solvent was distilled off from the filtrate
- additionEther was added to the residue
- filtrationthe precipitated crystals were collected by filtration
- washwashed with ether
Sources & evidence
- ORD record
- ord-0db605532b0b42ad8279c68bb28ca130
- Source dataset
- uspto-grants-1988_09
- Patent number
- US04771046
Reaction notes
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