Boc-Lys(Z)-OH → H-Glu(Bzl)-Pro-OMe trifluoroacetate

HRID 622637

Reaction equation

HRID 622637 reaction equation
N(C(OC(C)(C)C)=O)[C@H](C(O)=O)CCCCN[C:8]([O:10][CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:9].[NH2:28][C@H:29]([C:45]([N:47]1[CH2:55][CH2:54][CH2:53][C@H:48]1[C:49]([O:51][CH3:52])=[O:50])=[O:46])[CH2:30][CH2:31]CCNC(OCC1C=CC=CC=1)=O.[F:56][C:57]([C:60]([OH:62])=[O:61])([F:59])[F:58]>N(C(OC(C)(C)C)=O)[C@H](C(O)=O)CCC(=O)OCC1C=CC=CC=1>[NH2:28][C@H:29]([C:45]([N:47]1[CH2:55][CH2:54][CH2:53][C@H:48]1[C:49]([O:51][CH3:52])=[O:50])=[O:46])[CH2:30][CH2:31][C:8](=[O:9])[O:10][CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1.[F:56][C:57]([C:60]([OH:62])=[O:61])([F:59])[F:58]

Participants

4

Reactant 2

HCID 2724765Boc-Lys(Z)-OHHCID 131667640Methyl N6-((benzyloxy)carbonyl)-L-lysyl-L-prolinate, 2,2,2-trifluoroacetate salt

Product 1

HCID 131715717H-Glu(Bzl)-Pro-OMe trifluoroacetate

Reagents, catalysts & solvents 1

HCID 83589L-Glutamic acid, N-((1,1-dimethylethoxy)carbonyl)-, 5-(phenylmethyl) esterSolvent

Procedure

Instead of Boc-Lys(Z)-OH in (b), Boc-Glu(Bzl)-OH was used as a starting compound to obtain H-Glu(Bzl)-Pro-OMe trifluoroacetate (oil).

Sources & evidence

ORD record
ord-8b912040337c4ad59022cff53b29b689
Source dataset
uspto-grants-1988_09
Patent number
US04772587

Linked notes

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