6-Bromopyridine-3-carbonitrile → 6-(2-(Trifluoromethoxy)ethoxy)nicotinonitrile
Reaction equation
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[F:10][C:11]([F:17])([F:16])[O:12][CH2:13][CH2:14][OH:15]>>[F:10][C:11]([F:17])([F:16])[O:12][CH2:13][CH2:14][O:15][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][N:3]=1Participants
3
Procedure
The title compound is prepared in 95% yield (509 mg, colorless oil) from 6-bromonicotinonitrile (422 mg, 2.31 mmol) and 2-(trifluoromethoxy)ethanol (300 mg, 2.31 mmol) by the similar manner in Step-1 of Amine-101.
Sources & evidence
- ORD record
- ord-f77dfa4bbe0043d3a105b95e9fc27b47
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09302991B2
Reaction notes
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