Cyclopropanecarboxamide → Methyl 2-(cyclopropanecarboxamido)pyrimidine-4-carboxylate

Reaction equation

Cl[C:2]1[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][N:3]=1.[CH:12]1([C:15]([NH2:17])=[O:16])[CH2:14][CH2:13]1>>[CH:12]1([C:15]([NH:17][C:2]2[N:7]=[C:6]([C:8]([O:10][CH3:11])=[O:9])[CH:5]=[CH:4][N:3]=2)=[O:16])[CH2:14][CH2:13]1

Participants

Reactant 2

HCID 80376Cyclopropanecarboxamide

HCID 43811076Methyl 2-chloropyrimidine-4-carboxylate

Product 1

HCID 67509747Methyl 2-(cyclopropanecarboxamido)pyrimidine-4-carboxylate

Procedure

The title compound is prepared in quantitative yield (1.93 g, a pale yellow solid) from methyl 2-chloropyrimidine-4-carboxylate (1.50 g, 8.69 mmol) and cyclopropanecarboxamide by the similar manner in Step-1 of Carboxylic acid-4.

Sources & evidence

ORD record: ord-cd0932d17f7c4830b2c7075b30648345
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302991B2

Reaction notes

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