2-Aminopyrimidine-4-carboxylic acid → (R)-2-amino-N-(1-(3-(trifluoromethyl)phenyl)ethyl)pyrimidine-4-carboxamide
Reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([C@H:9]([NH2:11])[CH3:10])[CH:6]=[CH:7][CH:8]=1.[NH2:14][C:15]1[N:20]=[C:19]([C:21](O)=[O:22])[CH:18]=[CH:17][N:16]=1>>[NH2:14][C:15]1[N:20]=[C:19]([C:21]([NH:11][C@@H:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:12])([F:13])[F:1])[CH:4]=2)[CH3:10])=[O:22])[CH:18]=[CH:17][N:16]=1Participants
3
Procedure
The title compound is prepared in 72% yield (161 mg, a white solid) from (R)-1-(3-(trifluoromethyl)phenyl)ethanamine (136 mg, 0.72 mmol) and 2-aminopyrimidine-4-carboxylic acid (100 mg, 0.72 mmol) by the similar manner in Step-1 of Example 8.
Sources & evidence
- ORD record
- ord-f6129bfa0bbb43d7bbeb95968f719742
- Source dataset
- uspto-grants-2016_04