HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminopyridine-4-carboxylic acid → 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminopyridine-4-carboxylic acid | HCID 278396 | — |
| Reactant | HCID 67508831 | HCID 67508831 | — |
| Product | 2-amino-N-((6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide | HCID 67509665 | 29% |
Reaction Steps
The title compound is prepared in 29% yield (182 mg, a white solid) from (6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (473 mg, 1.95 mmol) and 2-aminoisonicotinic acid (269 mg, 1.95 mmol) by the similar manner in Step-1 of Example-8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09302991B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-729e19a3c2fd49c181aa3f8739096675 |
| Source note | uspto-grants-2016_04 |