2-Acetamidopyridine-4-carboxylic acid → 2-acetamido-N-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamide

HRID 623659

Reaction equation

HRID 623659 reaction equation
Cl.[Br:2][C:3]1[CH:4]=[C:5]([CH2:15][NH2:16])[CH:6]=[N:7][C:8]=1[O:9][CH2:10][C:11]([F:14])([F:13])[F:12].[C:17]([NH:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][N:29]=1)[C:24](O)=[O:25])(=[O:19])[CH3:18]>>[C:17]([NH:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][N:29]=1)[C:24]([NH:16][CH2:15][C:5]1[CH:6]=[N:7][C:8]([O:9][CH2:10][C:11]([F:12])([F:13])[F:14])=[C:3]([Br:2])[CH:4]=1)=[O:25])(=[O:19])[CH3:18]

Participants

3

Reactant 2

HCID 37744662-Acetamidopyridine-4-carboxylic acidHCID 67508543(5-Bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride

Product 1

HCID 675096872-acetamido-N-((5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methyl)isonicotinamideYield 61%

Procedure

The title compound is prepared in 61% yield (380 mg, a white solid) from (5-bromo-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)methanamine hydrochloride (450 mg, 1.4 mmol, Amine-67) and 2-acetamidoisonicotinic acid (250 mg, 1.4 mmol) by the similar manner in Step-1 of Example 8.

Sources & evidence

ORD record
ord-084033b3d7b1465b96b67eba2c665c9c
Source dataset
uspto-grants-2016_04
Patent number
US09302991B2

Linked notes

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