Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) → 1-Methoxy-4-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazolium tetrafluoroborate

HRID 623688

Reaction equation

[CH3:1][C:2]1[CH:6]=[N+:5]([O-:7])[N:4]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)[N:3]=1.[F:18][B-:19]([F:22])([F:21])[F:20].[CH3:23][O+](C)C>ClCCl>[F:18][B-:19]([F:22])([F:21])[F:20].[CH3:23][O:7][N+:5]1[N:4]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([F:15])([F:17])[F:16])=[CH:12][CH:13]=2)[N:3]=[C:2]([CH3:1])[CH:6]=1

Participants

Conditions

Temperature: 23 °C

Procedure

To a stirred solution of 4-methyl-2-[4-(trifluoromethyl)phenyl]-2H-1,2,3-triazole 1-oxide (i.e. the product of Step A, 5.22 g, 21.5 mmol) in dichloromethane (100 mL) was added trimethyloxonium tetrafluoroborate (4.13 g, 27.9 mmol). The reaction mixture was stirred at 23° C. for 65 h, then concentrated under reduced pressure to afford a crude mixture of the title compound as a brown oil which was used directly in the next step without further purification.

Workup

concentrationconcentrated under reduced pressure
customto afford a crude

Sources & evidence

ORD record: ord-0dd6ad38af624003b9fb69ef32ddf35a
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09302999B2

Linked notes

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