2-Bromo-4'-nitroacetophenone → 5-(2-(2-Chlorobenzyl)thiazol-4-yl)thiophen-2-amine

HRID 624239

Reaction equation

HRID 624239 reaction equation
BrCC(C1C=CC([N+]([O-])=O)=CC=1)=O.[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH2:21][C:22](=[S:24])[NH2:23].[C:25]1([CH2:31][C:32](=[S:34])[NH2:33])C=C[CH:28]=[CH:27][CH:26]=1>>[Cl:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[CH2:21][C:22]1[S:24][CH:28]=[C:27]([C:26]2[S:34][C:32]([NH2:33])=[CH:31][CH:25]=2)[N:23]=1

Participants

4

Reactant 3

HCID 668402-Bromo-4'-nitroacetophenoneHCID 7313682-PhenylethanethioamideHCID 28067852-(2-Chlorophenyl)ethanethioamide

Product 1

HCID 687505605-(2-(2-Chlorobenzyl)thiazol-4-yl)thiophen-2-amine

Procedure

The title compound was prepared as described in Example 806A, substituting 2-bromo-1-(5-nitrothiophen-2-yl)ethanone for 2-bromo-1-(4-nitrophenyl)ethanone and 2-(2-chlorophenyl)ethanethioamide for 2-phenylethanethioamide.

Sources & evidence

ORD record
ord-86da2cf31f0d447f987e1ce787aea6f5
Source dataset
uspto-grants-2016_04
Patent number
US09302989B2

Linked notes

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