4-Fluorobenzoyl chloride → 6-(2-Amino-ethyl)-5-(4-fluoro-phenyl)-1,3-dimethyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

Reaction equation

[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1.[F:23]C1C=CC(C(Cl)=O)=CC=1>>[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([C:13]2[CH:18]=[CH:17][C:16]([F:23])=[CH:15][CH:14]=2)=[C:11]2[C:6]([N:7]([CH3:22])[C:8](=[O:21])[N:9]([CH3:20])[C:10]2=[O:19])=[CH:5]1

Participants

Reactant 2

HCID 678794-Fluorobenzoyl chloride

HCID 867228796-(2-Amino-ethyl)-1,3-dimethyl-5-phenyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

Product 1

HCID 867229116-(2-Amino-ethyl)-5-(4-fluoro-phenyl)-1,3-dimethyl-1,6-dihydro-pyrrolo[3,4-d]pyrimidine-2,4-dione

Procedure

This compound was prepared analogously to Intermediate A by replacing benzoyl chloride (step 2) with 4-fluorobenzoyl chloride.

Sources & evidence

ORD record: ord-7197b6a1a33844d499dd3b81e6754682
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09303035B2

Reaction notes

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