Potassium Hydroxide → 9-Bromo-5,6-dihydrobenzo[F]imidazo[1,2-D][1,4]oxazepine-2-carboxylic acid

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]([CH2:18][CH2:19][OH:20])[CH:10]=[C:11]([C:13]([O:15]CC)=[O:14])[N:12]=2)=[C:4](F)[CH:3]=1.[OH-].[K+].Cl.C[N+](CCCC)(CCCC)CCCC>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[C:8]3[N:9]([CH:10]=[C:11]([C:13]([OH:15])=[O:14])[N:12]=3)[CH2:18][CH2:19][O:20][C:4]=2[CH:3]=1

Participants

Reactant 3

HCID 14797Potassium Hydroxide

HCID 567953Methyl tributylammonium hydrochloride

HCID 85472880Ethyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylate

Product 1

HCID 582043519-Bromo-5,6-dihydrobenzo[F]imidazo[1,2-D][1,4]oxazepine-2-carboxylic acid

Procedure

Ethyl 2-(4-bromo-2-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazole-4-carboxylate 27, potassium hydroxide and methyl tributylammonium hydrochloride were reacted at 65° C., cooled, and concentrated. The mixture was dissolved in ethanol and water to crystallize 28.