HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2-Dimethylpyrrolidine → [5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridin-2-yl]-(2,2-dimethyl-pyrrolidin-1-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2-Dimethylpyrrolidine | HCID 414773 | — |
| Reactant | 5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid | HCID 86674787 | — |
| Product | [5-Cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridin-2-yl]-(2,2-dimethyl-pyrrolidin-1-yl)-methanone | HCID 76284635 | — |
Reaction Steps
The title compound was synthesized in analogy to Example 47 b, using 5-cyclopropyl-6-(2,2,3,3,3-pentafluoro-propoxy)-pyridine-2-carboxylic acid (40 mg, 129 μmol) and 2,2-dimethylpyrrolidine (CAN 35018-15-6; 18 μL, 141 μmol) as starting materials and isolated (41 mg, 81%) as light-brown oil; LC-MS (UV peak area, ESI) 100%, 393.1611 [MH+].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09303012B2 |
| Source dataset | uspto-grants-2016_04 |
| ORD ID | ord-2b43050f123f420bb36c83effb3039bd |
| Source note | uspto-grants-2016_04 |