3-Bromo-2-chloro-6-methylpyridine → HCID 90202624, compound

HRID 625002

Reaction equation

Br[C:2]1[C:3]([Cl:9])=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[O:10]1[CH2:13][C:12](=[O:14])[CH2:11]1>>[Cl:9][C:3]1[C:2]([C:12]2([OH:14])[CH2:13][O:10][CH2:11]2)=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=1

Participants

Reactant 2

HCID 27344183-Bromo-2-chloro-6-methylpyridine

HCID 150242543-Oxetanone

Product 1

HCID 90202624HCID 90202624, compoundYield 71%

Procedure

In analogy to the procedure described in Example 130 a), 3-bromo-2-chloro-6-methylpyridine (CAN 185017-72-5, 5 g, 24.2 mmol) was reacted with oxetan-3-one (CAN 6704-31-0, 1.75 g, 1.42 mL, 24.2 mmol) to give the title compound (3.42 g, 71%) as off-white solid, MS (ESI): m/e=200.5 [MH+].

Sources & evidence

ORD record: ord-6e94af4091a6499abe54c42ce8a01fc4
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09303012B2

Linked notes

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