(S)-N-((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide → (1S)-1-[3-(Methylethyl)phenyl]ethylamine
Reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH:12][S@](C(C)(C)C)=O)[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]>CO>[CH:1]([C:4]1[CH:5]=[C:6]([C@@H:10]([NH2:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1)([CH3:3])[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The mixture of (S)—N—((S)-1-(3-isopropylphenyl)ethyl)-2-methylpropane-2-sulfinamide (6.1 g, 0.023 mol) in methanol was stirred at room temperature for 3 hours and then concentrated and evaporated with toluene for three times to give the titled compound which was without purification for next step.
Workup
- concentrationconcentrated
- customevaporated with toluene for three times
Sources & evidence
- ORD record
- ord-6aa35cfe6d984e308516c2debcf98c03
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09309227B2
Reaction notes
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