1-Methylimidazole → (4-Chlorophenyl)(1-ethyl-1H-imidazol-5-yl)methanone

Reaction equation

[CH2:1]([N:3]1[CH:7]=[CH:6][N:5]=[CH:4]1)[CH3:2].[Cl:8][C:9]1[CH:20]=[CH:19][C:12]([C:13](N(OC)C)=[O:14])=[CH:11][CH:10]=1.CN1C=CN=C1.FC1N=CC(C(N(OC)C)=O)=CC=1>>[Cl:8][C:9]1[CH:20]=[CH:19][C:12]([C:13]([C:7]2[N:3]([CH2:1][CH3:2])[CH:4]=[N:5][CH:6]=2)=[O:14])=[CH:11][CH:10]=1

Participants

Reactant 4

HCID 13901-Methylimidazole

HCID 815401-Ethyl-1H-imidazole

HCID 112756634-Chloro-N-methoxy-N-methylbenzamide

HCID 587671286-Fluoro-N-methoxy-N-methylpyridine-3-carboxamide2×

Product 1

HCID 46238207(4-Chlorophenyl)(1-ethyl-1H-imidazol-5-yl)methanone

Procedure

The title compound was prepared using 1-ethyl-1H-imidazole and 4-chloro-N-methoxy-N-methylbenzamide (Intermediate 18, step a) in place of 1-methyl-1H-imidazole and 6-fluoro-N-methoxy-N-methylpyridine-3-carboxamide, respectively, according to the procedure described for Intermediate 21, step c.