3-(4-Hydroxyphenyl)propionic acid → Benzenepropanoic acid, 4-hydroxy-, methyl ester
Reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[CH:4][CH:3]=1.Cl.O1CCOC[CH2:15]1>CO>[CH3:15][O:11][C:10](=[O:12])[CH2:9][CH2:8][C:5]1[CH:4]=[CH:3][C:2]([OH:1])=[CH:7][CH:6]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
After 3-(4-hydroxy-phenyl)propionic acid (3 g, 18 mmol) was added with MeOH (6 mL), 4M HCl/dioxane solution (18 mL, 72 mmol) was added thereto, and the mixture was stirred at room temperature for 3 hours. The reactant was concentrated, added with EtOAc, and then washed with NaCl aqueous solution. The organic layer was separated, dried with MgSO4, and filtered to obtain the title compound (3.26 g, 99%).
Workup
- additionwas added
- concentrationThe reactant was concentrated
- additionadded with EtOAc
- washwashed with NaCl aqueous solution
- customThe organic layer was separated
- dry with materialdried with MgSO4
- filtrationfiltered
Sources & evidence
- ORD record
- ord-ec3f833bd73143d4a3ef43c7709226b4
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447044B2
Reaction notes
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