Bromocyclopentane → 2-(Cyclopentylsulfanyl)pyridine-3-carboxylic acid

Reaction equation

[SH:1][C:2]1[N:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Br[CH:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1>>[CH:12]1([S:1][C:2]2[N:10]=[CH:9][CH:8]=[CH:7][C:3]=2[C:4]([OH:6])=[O:5])[CH2:16][CH2:15][CH2:14][CH2:13]1

Participants

Reactant 2

HCID 8728Bromocyclopentane

HCID 178524460HCID 178524460, compound

Product 1

HCID 167871172-(Cyclopentylsulfanyl)pyridine-3-carboxylic acid

Procedure

2-Mercapto-nicotinic acid (1.0 g, 6.44 mmol) and bromo-cyclopentane (2 mL, 19.33 mmol) were reacted in the same manner as in Step A of Preparation Example 1 to obtain the title compound, which was used in the next step without a separate purification process.

Sources & evidence

ORD record: ord-3a309bac34724c338a028dcc1296b76d
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Reaction notes

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