2-Propanethiol → 2-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl ester

HRID 62868

Reaction equation

[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8](Cl)[N:7]=1)=[O:5])[CH3:2].[CH3:13][CH:14]([SH:16])[CH3:15]>>[CH2:1]([O:3][C:4]([C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:16][CH:14]([CH3:15])[CH3:13])[N:7]=1)=[O:5])[CH3:2]

Participants

Reactant 2

HCID 63642-Propanethiol

HCID 22509306Ethyl 2-chloropyrimidine-4-carboxylate

Product 1

HCID 901183312-Isopropylsulfanyl-pyrimidine-4-carboxylic acid ethyl esterYield 68%

Procedure

2-Chloropyrimidine-4-carboxylic acid ethyl ester (0.024 g, 0.13 mmol) obtained in Step A and 2-propanethiol were reacted in the same manner as in Step A of Preparation Example 16 to obtain the title compound (0.02 g, 68%).

Sources & evidence

ORD record: ord-bb76834c5a184a2880af0b5f4d64a1de
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447044B2

Linked notes

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