Methanol → 2-Chloro-6-methoxypyridine-3-carboxylic acid

Reaction equation

[K].[Cl:2][C:3]1[N:11]=[C:10](Cl)[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6].[CH3:13][OH:14]>>[Cl:2][C:3]1[N:11]=[C:10]([O:14][CH3:13])[CH:9]=[CH:8][C:4]=1[C:5]([OH:7])=[O:6]

Participants

Reactant 3

HCID 887Methanol

HCID 8540472,6-Dichloronicotinic acid

HCID 5462222Potassium

Product 1

HCID 117692662-Chloro-6-methoxypyridine-3-carboxylic acidYield 52%

Procedure

Potassium botoxide (483 mg, 4.31 mmol) and MeOH (8 mL) were added to 2,6-dichloro-nicotinic acid (207 mg, 1.07 mmol), and the mixture was stirred using microwave at 60° C. for 1 hour. After the termination of the reaction, the reactant was filtered, and 1N HCl was added thereto at 0° C. to adjust the pH to 3. The solid was dried by N2 gas to obtain the title compound (106 mg, 52%).