Thionyl Chloride → 2-(3-Fluoro-4-methoxy-phenyl)-cyclopropanecarbonyl chloride
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:12][CH:11]2[C:13]([OH:15])=O)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].O=S(Cl)[Cl:18]>>[F:1][C:2]1[CH:3]=[C:4]([CH:10]2[CH2:12][CH:11]2[C:13]([Cl:18])=[O:15])[CH:5]=[CH:6][C:7]=1[O:8][CH3:9]Participants
3
Procedure
After 2-(3-fluoro-4-methoxy-phenyl)-cyclopropane carboxylic acid (0.848 g, 4.03 mmol) obtained in Step A was dissolved in anhydrous MC (10 mL), SOCl2 (3 mL, 40.34 mmol) was added thereto, and the mixture was stirred at room temperature for 18 hours. After the termination of the reaction, the reactant was concentrated under reduced pressure to obtain the title compound, which was used in the next step without a separate purification process
Workup
- additionwas added
- customAfter the termination of the reaction
- concentrationthe reactant was concentrated under reduced pressure
Sources & evidence
- ORD record
- ord-9cd02290e85548a5a128b7969d4c6865
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447044B2
Reaction notes
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