Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate → 3-[3,5-Difluoro-4-(4-isopropylsulfanyl-2-methyl-pyrimidin-5-yl methoxy)-phenyl]-propionic acid ethyl ester
Reaction equation
[CH:1]([S:4][C:5]1[C:10]([CH2:11][OH:12])=[CH:9][N:8]=[C:7]([CH3:13])[N:6]=1)([CH3:3])[CH3:2].[CH2:14]([O:16][C:17](=[O:29])[CH2:18][CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23](O)=[C:22]([F:28])[CH:21]=1)[CH3:15]>>[CH2:14]([O:16][C:17](=[O:29])[CH2:18][CH2:19][C:20]1[CH:25]=[C:24]([F:26])[C:23]([O:12][CH2:11][C:10]2[C:5]([S:4][CH:1]([CH3:3])[CH3:2])=[N:6][C:7]([CH3:13])=[N:8][CH:9]=2)=[C:22]([F:28])[CH:21]=1)[CH3:15]Participants
3
Procedure
(4-Isopropylsulfanyl-2-methyl-pyrimidin-5-yl)-methanol (0.006 g, 0.03 mmol) obtained in Step B of Preparation Example 40 and 3-(3,5-difluoro-4-hydroxy-phenyl)-propionic acid ethyl ester (0.007 g, 0.03 mmol) obtained in Step D of Preparation Example 2 were reacted in the same manner as in Step A of Example 24 to obtain the title compound (0.009 g, 72%).