Cyclopropylamine → HCID 71542011, compound

HRID 629515

Reaction equation

[C:1]12([C:11]3[CH:21]=[CH:20][C:14]([O:15][CH2:16][C:17](O)=[O:18])=[CH:13][CH:12]=3)[CH2:10][CH:5]3[CH2:6][CH:7]([CH2:9][CH:3]([CH2:4]3)[CH2:2]1)[CH2:8]2.[CH:22]1([NH2:25])[CH2:24][CH2:23]1>>[C:1]12([C:11]3[CH:12]=[CH:13][C:14]([O:15][CH2:16][C:17]([NH:25][CH:22]4[CH2:24][CH2:23]4)=[O:18])=[CH:20][CH:21]=3)[CH2:2][CH:3]3[CH2:9][CH:7]([CH2:6][CH:5]([CH2:4]3)[CH2:10]1)[CH2:8]2

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 625381PMID26882240-Compound-8

Product 1

HCID 71542011HCID 71542011, compoundYield 88.2%

Procedure

The title compound was prepared from 2-(4-(adamantan-1-yl)phenoxy)acetic acid (0.2 g, 0.69 mmol) and cyclopropylamine (0.039 g, 0.69 mmol) according to the example 1, which was given 2-(4-(adamantan-1-yl)phenoxy)-N-cyclopropylacetamide as a white solid (0.198 g, 87.4% yield).

Sources & evidence

ORD record: ord-f36380b57391480a98687b968e4bd324
Source dataset: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09315507B2

Linked notes

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