6-Nitro-2,3-dihydrobenzofuran-5-amine → 2,3-Dihydrobenzofuran-5,6-diamine
Reaction equation
[NH2:1][C:2]1[C:3]([N+:11]([O-])=O)=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1.[H][H]>CCO.[Pd]>[NH2:1][C:2]1[C:3]([NH2:11])=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1Participants
5
Reactant 2
Product 1
Reagents, catalysts & solvents 2
Procedure
The product obtained in Step 5 (2.5 g, 13.9 mmol) and Pd/C (0.5 g) were dissolved in EtOH (50 mL), hydrogenated in a Parr hydrogenation apparatus at room temperature and a hydrogen pressure of 50 PSI for 12 h. The catalyst was removed by filtration, the ethanol solution of the product was directly used in the next step of reaction.
Workup
- customThe catalyst was removed by filtration
- customthe ethanol solution of the product was directly used in the next step of reaction
Sources & evidence
- ORD record
- ord-02a7d3eeb73a4c6fbc41806e5940cffe
- Source dataset
- uspto-grants-2016_04
- Patent number
- US09315513B2
Reaction notes
Loading…