Formaldehyde → (3-chloro-2H-indazol-2-yl)methanol

HRID 630019

Reaction equation

HRID 630019 reaction equation
[Cl:1][C:2]1[NH:3][N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2.[CH2:11]=[O:12]>O>[Cl:1][C:2]1[N:3]([CH2:11][OH:12])[N:4]=[C:5]2[C:10]=1[CH:9]=[CH:8][CH:7]=[CH:6]2

Participants

4

Reactant 2

HCID 712FormaldehydeHCID 958943-Chloro-1H-indazole

Product 1

HCID 59589510(3-chloro-2H-indazol-2-yl)methanolYield 99.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a 250 mL round bottom flask, 3-chloro-2H-indazole (1.95 g, 10 mmol), 30% HCHO (2 mL, 20 mmol) were mixed in water (10 mL). The reaction mixture was refluxed for 2 hours. After cooling down to room temperature, the solid was filtered, washed with water, and dried under vacuum to provide (3-chloro-2H-indazol-2-yl)methanol (1.82 g, 99% yield).

Workup

  1. temperatureThe reaction mixture was refluxed for 2 hours
  2. filtrationthe solid was filtered
  3. washwashed with water
  4. customdried under vacuum

Sources & evidence

ORD record
ord-df448b7d99c644bc9ce7349e01de42a3
Source dataset
uspto-grants-2016_04
Patent number
US09315521B2

Linked notes

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