Reaction equation
[CH:1]1([NH:6][C:7]2[C:12]([CH3:13])=[C:11]([CH3:14])[N:10]=[C:9]([NH:15][CH2:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=3)[N:8]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH:23]12CC(CC1)C[CH:24]2N>>[CH:5]12[CH2:4][CH:3]([CH2:23][CH2:24]1)[CH2:2][CH:1]2[NH:6][C:7]1[C:12]([CH3:13])=[C:11]([CH3:14])[N:10]=[C:9]([NH:15][CH2:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=2)[N:8]=1Participants
Procedure
The titled compound was synthesized according to the procedure described for preparation of N4-cyclopentyl-5,6-dimethyl-N2-(pyridin-2-ylmethyl)pyrimidine-2,4-diamine (Example 29) using bicyclo[2.2.1]hept-2-ylamine instead of cyclopentanamine. The crude material was purified by column chromatography eluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1), and then the final product was washed with diethyl ether to afford the titled compound as a white solid. 1H NMR (300 MHz, DMSO-d6) δ ppm 0.80-0.94 (m, 1H), 0.98-1.06 (m, 1H), 1.10-1.19 (m, 1H), 1.26-1.36 (m, 2H), 1.48-1.56 (m, 1H), 1.65-1.77 (m, 1H), 1.93 (s, 3H), 2.07 (s, 3H), 2.12-2.20 (m, 1H), 2.22-2.30 (m, 1H), 2.50-2.58 (m, 1H), 3.70-3.80 (m, 1H) 4.42-4.51 (m, 2H), 7.20-7.27 (m, 1H) 7.50-7.58 (m, 1H), 7.68-7.80 (m, 1H), 8.65 (d, J=4.92 Hz, 1H); MS (ESI) m/z 324.0 (M+1)+.
Workup
- customThe titled compound was synthesized
- customThe crude material was purified by column chromatography
- washeluting with mixture of chloroform/ethanol/20% water solution of ammonia (200:10:1)
- washthe final product was washed with diethyl ether
Sources & evidence
- ORD record
- ord-3ae169063acc4b0cae478695d386ae3f
- Source dataset
- uspto-grants-2016_09
- Patent number
- US09447051B2
Linked notes
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