6-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid → 6-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

HRID 632080

Reaction equation

HRID 632080 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=2[CH3:17])[CH:5]=[CH:6][CH:7]=1.[NH2:18][C:19]([CH2:26][CH3:27])([CH2:24][CH3:25])[C:20]([NH:22][CH3:23])=[O:21]>>[CH2:24]([C:19]([NH:18][C:14]([C:12]1[CH:11]=[CH:10][C:9]([CH3:17])=[C:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=2)[N:13]=1)=[O:16])([C:20](=[O:21])[NH:22][CH3:23])[CH2:26][CH3:27])[CH3:25]

Participants

3

Reactant 2

HCID 710878026-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acidHCID 798103702-Amino-2-ethyl-N-methyl-butyramide

Product 1

HCID 710935046-(3-Chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid (1-ethyl-1-methylcarbamoyl-propyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-(3-chloro-phenyl)-5-methyl-pyridine-2-carboxylic acid (Example 49 e) and 2-amino-2-ethyl-N-methyl-butyramide as starting materials, MS (LC/MS): 374.2 [M+H]+.

Sources & evidence

ORD record
ord-0b53f64974b64836a91b753c7f8805db
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

Loading…