(S)-alpha-amino-cyclopropanepropanamide → 6-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

HRID 632164Notes

Reaction equation

HRID 632164 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[N:11]=[C:10]([C:12]([OH:14])=O)[CH:9]=[CH:8][C:7]=2[CH3:15])[CH2:3][CH2:2]1.[NH2:16][C@@H:17]([CH2:21][CH:22]1[CH2:24][CH2:23]1)[C:18]([NH2:20])=[O:19]>>[C:18]([C@@H:17]([NH:16][C:12]([C:10]1[CH:9]=[CH:8][C:7]([CH3:15])=[C:6]([O:5][CH2:4][CH:1]2[CH2:2][CH2:3]2)[N:11]=1)=[O:14])[CH2:21][CH:22]1[CH2:24][CH2:23]1)(=[O:19])[NH2:20]

Participants

3

Reactant 2

HCID 53964035(S)-alpha-amino-cyclopropanepropanamideHCID 710875996-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid

Product 1

HCID 711056106-Cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid ((S)-1-carbamoyl-2-cyclopropyl-ethyl)-amide

Procedure

The title compound was synthesized in analogy to Example 1, using 6-cyclopropylmethoxy-5-methyl-pyridine-2-carboxylic acid (Example 36 d) and (S)-2-amino-3-cyclopropyl-propionamide (CAN 156077-93-9) as starting materials, MS (EI): m/e=318.2 [M+H]+.

Sources & evidence

ORD record
ord-2bd110ea9d0448f3ac4b816ff9b34589
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Reaction notes

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