2-Amino-3,3-dimethylbutanamide hydrochloride → N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-5-cyclopropyl-6-(cyclopropylmethoxy)picolinamide

HRID 632240

Reaction equation

HRID 632240 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.Cl.[NH2:19][CH:20]([C:24]([CH3:27])([CH3:26])[CH3:25])[C:21]([NH2:23])=[O:22]>>[NH2:23][C:21](=[O:22])[CH:20]([NH:19][C:15](=[O:17])[C:7]1[CH:6]=[CH:5][C:4]([CH:1]2[CH2:2][CH2:3]2)=[C:9]([O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[N:8]=1)[C:24]([CH3:27])([CH3:26])[CH3:25]

Participants

3

Reactant 2

HCID 509880582-Amino-3,3-dimethylbutanamide hydrochlorideHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 71087686N-(1-Amino-3,3-dimethyl-1-oxobutan-2-yl)-5-cyclopropyl-6-(cyclopropylmethoxy)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and 2-amino-3,3-dimethyl-butanamide hydrochloride (1:1) (CAN 359844-68-1) as starting materials, LC-MS (UV peak area/ESI) 100%, 346.2113 (M+H)+.

Sources & evidence

ORD record
ord-3897ae73403e4578b372ee26463ce570
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

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