3-Amino-3-methylbutan-1-ol → 5-Cyclopropyl-6-(cyclopropylmethoxy)-N-(4-hydroxy-2-methylbutan-2-yl)picolinamide

HRID 632258

Reaction equation

HRID 632258 reaction equation
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([OH:17])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:14][CH2:13]2)[CH2:3][CH2:2]1.[NH2:18][C:19]([CH3:24])([CH3:23])[CH2:20][CH2:21][OH:22]>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:15]([NH:18][C:19]([CH3:24])([CH2:20][CH2:21][OH:22])[CH3:23])=[O:17])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:13][CH2:14]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 6410003-Amino-3-methylbutan-1-olHCID 710873465-Cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 710877645-Cyclopropyl-6-(cyclopropylmethoxy)-N-(4-hydroxy-2-methylbutan-2-yl)picolinamide

Procedure

The title compound was synthesized in analogy to Example 1, using 5-cyclopropyl-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 42 a) and 3-amino-3-methyl-butan-1-ol (CAN 42514-50-1) as starting materials, LC-MS (UV peak area/ESI) 100%, 319.1 (M+H)+.

Sources & evidence

ORD record
ord-93e7ca51e2af428d9cec48aa9f2ae025
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

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