Methyl 2-amino-2-ethylbutanoate hydrochloride → 2-([5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carbonyl]-amino)-2-ethyl-butyric acid methyl ester

HRID 632273

Reaction equation

HRID 632273 reaction equation
[F:1][C:2]([F:25])([F:24])[CH2:3][N:4]([CH2:19][C:20]([F:23])([F:22])[F:21])[C:5]1[CH:6]=[CH:7][C:8]([C:16](O)=[O:17])=[N:9][C:10]=1[O:11][CH2:12][CH:13]1[CH2:15][CH2:14]1.Cl.[NH2:27][C:28]([CH2:35][CH3:36])([CH2:33][CH3:34])[C:29]([O:31][CH3:32])=[O:30]>>[CH3:32][O:31][C:29](=[O:30])[C:28]([NH:27][C:16]([C:8]1[CH:7]=[CH:6][C:5]([N:4]([CH2:3][C:2]([F:1])([F:25])[F:24])[CH2:19][C:20]([F:22])([F:21])[F:23])=[C:10]([O:11][CH2:12][CH:13]2[CH2:15][CH2:14]2)[N:9]=1)=[O:17])([CH2:35][CH3:36])[CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 75488114Methyl 2-amino-2-ethylbutanoate hydrochlorideHCID 866747745-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid

Product 1

HCID 714912282-([5-[Bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carbonyl]-amino)-2-ethyl-butyric acid methyl ester

Procedure

The title compound was synthesized in analogy to Example 1, using 5-[bis-(2,2,2-trifluoro-ethyl)-amino]-6-cyclopropylmethoxy-pyridine-2-carboxylic acid (Example 162 b) and methyl 2-amino-2-ethylbutanoate hydrochloride (CAN 92398-54-4) as starting materials, MS (EI): m/e=500.1 [M+H]+.

Sources & evidence

ORD record
ord-f0e4b020be8346798e53184a46eed5fa
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

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