Methyl 5-bromo-6-(cyclopropylmethoxy)picolinate → 6-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid methyl ester

HRID 632289

Reaction equation

HRID 632289 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8](Br)=[C:7]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[N:6]=1)=[O:4].C(O)(=O)C(O)=O.[NH:23]1[C:26]2([CH2:29][O:28][CH2:27]2)[CH2:25][CH2:24]1>>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([N:23]2[C:26]3([CH2:29][O:28][CH2:27]3)[CH2:25][CH2:24]2)=[C:7]([O:12][CH2:13][CH:14]2[CH2:16][CH2:15]2)[N:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 71087286Methyl 5-bromo-6-(cyclopropylmethoxy)picolinateHCID 713039926-Oxa-1-azaspiro[3.3]heptane oxalate

Product 1

HCID 710874846-Cyclopropylmethoxy-5-(6-oxa-1-aza-spiro[3.3]hept-1-yl)-pyridine-2-carboxylic acid methyl ester

Procedure

The title compound was synthesized in analogy to the procedure described in Example 32 a), using 5-bromo-6-(cyclopropylmethoxy)-pyridine-2-carboxylic acid methyl ester (Example 9 d) and 6-oxa-1-azaspiro[3.3]heptane, oxalate salt (CAN 1359655-43-8) as starting materials. MS (EI): m/e=305.0 [M+H]+.

Sources & evidence

ORD record
ord-721af8dd044f448996a2a915dc991dce
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

Loading…