Ethyl 2-amino-2-ethylbutanoate hydrochloride → 2-Ethyl-2-{[6-(tetrahydro-furan-2-ylmethoxy)-5-trifluoromethyl-pyridine-2-carbonyl]-amino}-butyric acid ethyl ester

HRID 632313

Reaction equation

HRID 632313 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][O:7][C:8]1[N:13]=[C:12]([C:14]([OH:16])=O)[CH:11]=[CH:10][C:9]=1[C:17]([F:20])([F:19])[F:18].Cl.[NH2:22][C:23]([CH2:31][CH3:32])([CH2:29][CH3:30])[C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH2:27]([O:26][C:24](=[O:25])[C:23]([CH2:31][CH3:32])([NH:22][C:14]([C:12]1[CH:11]=[CH:10][C:9]([C:17]([F:20])([F:19])[F:18])=[C:8]([O:7][CH2:6][CH:2]2[CH2:3][CH2:4][CH2:5][O:1]2)[N:13]=1)=[O:16])[CH2:29][CH3:30])[CH3:28]

Participants

3

Reactant 2

HCID 24201639Ethyl 2-amino-2-ethylbutanoate hydrochlorideHCID 710876466-((Tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acid

Product 1

HCID 710877822-Ethyl-2-{[6-(tetrahydro-furan-2-ylmethoxy)-5-trifluoromethyl-pyridine-2-carbonyl]-amino}-butyric acid ethyl ester

Procedure

The title compound was synthesized in analogy to Example 1, using 6-((tetrahydrofuran-2-yl)methoxy)-5-(trifluoromethyl)picolinic acid and ethyl 2-amino-2-ethylbutanoate hydrochloride (CAN 1135219-29-2) as starting materials. MS (EI): m/e=433.4 [M+H]+.

Sources & evidence

ORD record
ord-9cd8bdfd44dd4897984512c5fd667b13
Source dataset
uspto-grants-2016_04
Patent number
US09321727B2

Linked notes

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