4-Ethoxyphenol → HCID 23048282, compound

HRID 63266

Reaction equation

HRID 63266 reaction equation
[CH2:1]([O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[CH3:2].[Br:11]Br>C(Cl)(Cl)Cl>[Br:11][C:8]1[CH:9]=[C:4]([O:3][CH2:1][CH3:2])[CH:5]=[CH:6][C:7]=1[OH:10]

Participants

4

Reactant 2

HCID 121504-EthoxyphenolHCID 24408Bromine

Product 1

HCID 23048282HCID 23048282, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 4-(ethyloxy)phenol (Commercial eg Aldrich) (1.0 g) in chloroform (5 ml) cooled to 0° C. was added bromine (1.26 g) dropwise over 20 min. The resulting mixture was stirred at 25 C. for 2 h, before washing sequentially with aqueous sodium bicarbonate, and brine. The organics were dried over sodium sulphate, filtered and concentrated in vacuo to yield the title compound, 1.8 g

Workup

  1. washbefore washing sequentially with aqueous sodium bicarbonate, and brine
  2. dry with materialThe organics were dried over sodium sulphate
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b2f2eff8966742a39008bcd641da3c42
Source dataset
uspto-grants-2016_09
Patent number
US09447074B2

Linked notes

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