Acetonitrile → 3-(4-(Cyclohexylmethoxy)pyrimidin-2-yl)-3-oxopropanenitrile

Reaction equation

[CH:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([C:15]([O:17]C)=O)[N:10]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:19][C:20]#[N:21]>>[CH:1]1([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([C:15](=[O:17])[CH2:19][C:20]#[N:21])[N:10]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 86694671HCID 86694671, compound

Product 1

HCID 866946703-(4-(Cyclohexylmethoxy)pyrimidin-2-yl)-3-oxopropanenitrile

Procedure

CH3CN addition to methyl 4-(cyclohexylmethoxy)pyrimidine-2-carboxylate following the method described in Example 6 gives 3-(4-(cyclohexylmethoxy)pyrimidin-2-yl)-3-oxopropanenitrile.

Sources & evidence

ORD record: ord-6cada30eb21b4f879c49180d124dc780
Source dataset: uspto-grants-2016_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09447078B2

Reaction notes

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