Cycloheptanone Oxime → 3-(3-(4-(2-chlorophenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

HRID 635273

Reaction equation

HRID 635273 reaction equation
[C:1]1(=[N:8][OH:9])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][C:26](OCC)=O)[CH2:19][CH2:18]1>>[Cl:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[CH:17]1[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][CH2:25][C:26]2[O:9][N:8]=[C:1]3[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][C:2]=23)[CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 137457Cycloheptanone OximeHCID 17773194Ethyl 4-(4-(2-chlorophenyl)piperidin-1-yl)-n-butyrate

Product 1

HCID 599393683-(3-(4-(2-chlorophenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole

Procedure

By the same reaction and treatment as in Example 48 using cycloheptanone oxime and ethyl 4-(4-(2-chlorophenyl)piperidin-1-yl)-n-butyrate, 3-(3-(4-(2-chlorophenyl)piperidin-1-yl)propyl)-5,6,7,8-tetrahydro-4H-cyclohepta[c]isoxazole is obtained.

Sources & evidence

ORD record
ord-1032919bf37c4b869bfefd63b7524087
Source dataset
uspto-grants-2001_02
Patent number
US06187774B1

Linked notes

Loading…