4-Fluorobenzaldehyde → 4-Fluorobenzoyl chloride

HRID 635544

Reaction equation

Cl[C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([Cl:7])=[O:6].FC1C=CC(C=O)=CC=1>>[F:11][C:10]1[CH:9]=[CH:8][C:4]([C:5]([Cl:7])=[O:6])=[CH:3][CH:2]=1

Participants

Reactant 2

HCID 680234-Fluorobenzaldehyde

HCID 27365483-Chloro-4-fluorobenzoyl Chloride

Product 1

HCID 678794-Fluorobenzoyl chloride

Procedure

This object is achieved by a process for the preparation of 3-chloro-4-fluorobenzoyl chloride. It comprises reacting 4-fluorobenzaldehyde with a chlorinating agent in the presence of a free-radical initiator in the presence or absence of a solvent at from −20 to 200° C. to give 4-fluorobenzoyl chloride, and reacting the 4-fluorobenzoyl chloride with a chlorinating agent in the presence of a chlorination catalyst in the presence or absence of a solvent at from −20 to 200° C. to give 3-chloro-4-fluorobenzoyl chloride.

Workup

customat from −20 to 200° C.

Sources & evidence

ORD record: ord-31cc3ee68c6545349a557221c4de7ed5
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06187952B1

Linked notes

Loading…