Water → 1-Butyl-2-oxo-quinoline-4-carboxylic acid
Reaction equation
[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([O:17]CCCC)=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4].[OH-].[Na+].O>O1CCOCC1>[CH2:1]([N:5]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]([C:15]([OH:17])=[O:16])=[CH:7][C:6]1=[O:22])[CH2:2][CH2:3][CH3:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 2.04 g (6.77 mmols) of Compound b, 0.54 g of sodium hydroxide, 40 ml of water and 40 mt of dioxane was stirred at room temperature for 30 minutes. After concentration under reduced pressure, the residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1) to give 1.44 g (yield: 87%) of Compound a.
Workup
- concentrationAfter concentration under reduced pressure
- customthe residue was purified by silica gel column chromatography (eluting solvent: chloroform/methanol=5/1)
Sources & evidence
- ORD record
- ord-0b7ac1002a9c48df9ec7bd4af81498e1
- Source dataset
- uspto-grants-1993_09
- Patent number
- US05248684
Reaction notes
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