HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4,6-Dichloro-2-(methylthio)pyrimidine | HCID 80531 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 6-chloro-2-(methylthio)-N-(prop-2-ynyl)pyrimidine-4-amine | HCID 90303691 | 99.4% |
Reaction Conditions
| Temperature | 60 °C |
|---|
Reaction Steps
A mixture of 1.00 g (5.13 mmol) of 4,6-dichloro-2-(methylthio)pyrimidine and 0.7 ml (10.3 mmol) of propargylamine in 10 ml of acetonitrile was stirred for 12 hours at 60° C. The reaction solution was poured onto cold water. Then, the formed precipitate was filtered, washed several times with cold water and dried. 1.09 g of a light yellow solid were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09447095B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-01225f880448429ca0699b60ca00ba14 |
| Source note | uspto-grants-2016_09 |