1,4-Dioxane hydrochloride → HCID 54539135, compound

Reaction equation

C([N:8]([C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:12]=1)[CH2:9][CH3:10])(OC(C)(C)C)=O.Cl.O1CCOCC1>>[CH2:9]([NH:8][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[N:12]=1)[CH3:10]

Participants

Reactant 2

HCID 204431481,4-Dioxane hydrochloride

HCID 21257558HCID 21257558, compound

Product 1

HCID 54539135HCID 54539135, compound

Procedure

A solution of ethyl 2-(N-Boc-N-ethylamino)-6-pyridylacetate (1.5 g, 4.87 mmol) and 4M HCl/dioxane (5 mL, 20 mol) was stirred at RT overnight, then was concentrated. Reconcentration from toluene gave the title compound as white solid: MS (ES) m/e 209 (M+H)+.

Workup

concentrationwas concentrated

Sources & evidence

ORD record: ord-6e4cfb451cba429b8fe195d1437e8634
Source dataset: uspto-grants-2001_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06191304B1

Reaction notes

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