Formic Acid → HCID 118597990, compound

HRID 63643Notes

Reaction equation

HRID 63643 reaction equation
[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[CH2:3][O:2]1.[CH:11](O)=[O:12]>>[CH2:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH:10][CH:11]=[O:12])=[CH:9][C:4]=2[CH2:3][O:2]1

Participants

3

Reactant 2

HCID 284Formic AcidHCID 124453391,3-Dihydro-2-benzofuran-5-amine

Product 1

HCID 118597990HCID 118597990, compoundYield 69%

Procedure

1,3-Dihydro-2-benzofuran-5-amine (300 mg, 2.2 mmol) was added to HCOOH (10 mL), and the reaction was stirred at reflux overnight. The reaction was concentrated, basified to pH=8 with sat Na2CO3, and extracted with EtOAc. Organics were washed with brine, dried (Na2SO4), and concentrated to give 250 mg (69%) of N-(1,3-dihydro-2-benzofuran-5-yl)formamide as a yellow oil.

Workup

  1. temperatureat reflux overnight
  2. concentrationThe reaction was concentrated
  3. extractionextracted with EtOAc
  4. washOrganics were washed with brine
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-7535fa64e1b44f0aa936eef954ce8d4b
Source dataset
uspto-grants-2016_09
Patent number
US09447046B2

Reaction notes

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